Drug expiration dating mixture
The box of prescription drugs had been forgotten in a back closet of a retail pharmacy for so long that some of the pills predated the 1969 moon landing.Most were 30 to 40 years past their expiration dates -- possibly toxic, probably worthless.But to Lee Cantrell, who helps run the California Poison Control System, the cache was an opportunity to answer an enduring question about the actual shelf life of drugs: Could these drugs from the bell-bottom era still be potent?
Both the expiration date of the product used as the active ingredient, as well as the life of all of the ingredients used in compounding, must be taken into account when determining an appropriate expiration date for the compounded drug.The findings surprised both researchers: A dozen of the 14 compounds were still as potent as they were when they were manufactured, some at almost 100 percent of their labeled concentrations.Experts say the United States might be squandering a quarter of the money spent on health care. All drugs deteriorate over time in terms of potency and stability.
Compounding pharmacists have to take special care to consider the long-term potential effects on stability of combining active ingredients with established expiration dates with other substances, making sure that sub-potent preparations aren’t the result of compounding.Tests on the decades-old drugs including antihistamines, pain relievers and stimulants.